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Toll Like Receptor 4 Gene in Triple Breast Cancer: Prognostic Relevance
CC BY 4.0 · Indian J Med Paediatr Oncol 2024; 45(S 01): S1-S16
DOI: DOI: 10.1055/s-0044-1788218
*Corresponding author: (e-mail: mukherjeen@nirrch.res.in)
**Co-corresponding author: (e-mail: pratikchandrani@gmail.com)
Abstract
Background: Breast cancer (BC) is one of the leading cancers among Indian women. Triple-negative breast cancer (TNBC) which lacks ER, PR, and HER2 receptors is a subtype of BC that accounts for 15 to 20% of BC cases. Present study envisages the immunomodulatory role of Toll like receptor (TLR) in pathogenesis of TNBC.
Methods: For this, the expression of TLR4 pathway-associated genes was examined in TNBC tumor by immunofluorescence imaging and ELISA. Also, the same was validated in TCGA TNBC transcriptome dataset.
Results: The results of the analysis showed the difference in TLR4 expression in tumor nest and in stromal cell compartment of TNBC tumors. Also, a significant correlation (r = 0.99, p = 0.04) in expression between TLR4 and IFNϒ was observed in immune cell low TNBC patients. Interestingly, analysis of TNBC TCGA datasets indicated longer survival probability in TNBC patients with high TLR 4 and IFNϒ.
Conclusion: Our data show a synergistic association of TLR4 and IFNϒ signaling in pathogenesis of TNBC.
Publication History
Article published online:
08 July 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
*Corresponding author: (e-mail: mukherjeen@nirrch.res.in)
**Co-corresponding author: (e-mail: pratikchandrani@gmail.com)
Abstract
Background: Breast cancer (BC) is one of the leading cancers among Indian women. Triple-negative breast cancer (TNBC) which lacks ER, PR, and HER2 receptors is a subtype of BC that accounts for 15 to 20% of BC cases. Present study envisages the immunomodulatory role of Toll like receptor (TLR) in pathogenesis of TNBC.
Methods: For this, the expression of TLR4 pathway-associated genes was examined in TNBC tumor by immunofluorescence imaging and ELISA. Also, the same was validated in TCGA TNBC transcriptome dataset.
Results: The results of the analysis showed the difference in TLR4 expression in tumor nest and in stromal cell compartment of TNBC tumors. Also, a significant correlation (r = 0.99, p = 0.04) in expression between TLR4 and IFNϒ was observed in immune cell low TNBC patients. Interestingly, analysis of TNBC TCGA datasets indicated longer survival probability in TNBC patients with high TLR 4 and IFNϒ.
Conclusion: Our data show a synergistic association of TLR4 and IFNϒ signaling in pathogenesis of TNBC.
No conflict of interest has been declared by the author(s).
Publication History
Article published online:
08 July 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India